منابع مشابه
HMM-based databases in InterPro
Protein family databases are an important resource for protein annotation and understanding protein evolution and function. In recent years hidden Markov models (HMMs) have become one of the key technologies used for detection of members of these families. This paper reviews the Pfam, TIGRFAMs and SMART databases that use the profile-HMMs provided by the HMMER package.
متن کاملEffectiveness of HMM-based retrieval on large databases
We have investigated the performance of a hidden Markov model QBH retrieval system on a large musical database. The database is synthetic, generated from statistics gleaned from our (smaller) database of musical excerpts from various genres. This paper reports the performance of several variations of our retrieval system against different types of synthetic queries on the large database, where ...
متن کاملInteractive InterPro-based comparisons of proteins in whole genomes
MOTIVATION The SWISS-PROT group at the EBI has developed the Proteome Analysis Database utilizing existing resources and providing comprehensive and integrated comparative analysis of the predicted protein coding sequences of the complete genomes of bacteria, archaea and eukaryotes. The Proteome Analysis Database is accompanied by a program that has been designed to carry out interactive InterP...
متن کاملInterPro, progress and status in 2005
InterPro, an integrated documentation resource of protein families, domains and functional sites, was created to integrate the major protein signature databases. Currently, it includes PROSITE, Pfam, PRINTS, ProDom, SMART, TIGRFAMs, PIRSF and SUPERFAMILY. Signatures are manually integrated into InterPro entries that are curated to provide biological and functional information. Annotation is pro...
متن کاملInterPro: Quick tour
Classifying proteins into families and identifying important domains and sites is invaluable for helping biologists to identify distantly related proteins and to predict their functions. A daunting array of resources, each with different strengths and weaknesses, is now available for searching genomes and proteomes with ‘protein signatures’ – diagnostic entities that are used to recognise a par...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2002
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/3.3.236